
SZL P1-41

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CAS No. | 222716-34-9 | Cat. No. | BCP20701 |
Name | SZL P1-41 | ||
Synonyms | SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III; | ||
SMILES | |||
Chemical Name | |||
Formula | C24H24N2O3S | M. Wt | 420.52 |
Purity | 98% | Storage | Store at 4-8°C |
Description | SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes. target: Skp2 In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis. In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. |
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