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SZL P1-41 Chemical Structure

SZL P1-41

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20701CAS No. :222716-34-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 222716-34-9 Cat. No. BCP20701
Name SZL P1-41
Synonyms SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III;
SMILES
Chemical Name
Formula C24H24N2O3S M. Wt 420.52
Purity 98% Storage Store at 4-8°C
Description SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes. target: Skp2 In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis. In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
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