SG2057 New
Data Sheet
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| CAS No. | 260417-62-7 | Cat. No. | BCP46387 |
| Name | SG2057 | ||
| Synonyms | SG-2057; SG 2057; | ||
| SMILES | COC1=C(C=C2C(=C1)C(=O)N3CC(=C)CC3C=N2)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=C)CN6C5=O)OC | ||
| Chemical Name | |||
| Formula | C33H36N4O6 | M. Wt | 584.66 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48 h period. Significant antitumor activity was demonstrated in several human tumor xenograft models. | ||
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