Irosustat

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29882CAS No. ：288628-05-7Purity：98%

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CAS No.	288628-05-7	Cat. No.	BCP29882
Name	Irosustat
Synonyms	STX64; STX-64; STX 64; BN83495; BN-83495; BN 83495; 667-Coumate;667 coumate;STX-64PC;
SMILES	C1CCC2=C(CC1)C(=O)OC3=C2C=CC(=C3)OS(=O)(=O)N
Chemical Name
Formula	C14H15NO5S	M. Wt	309.34
Purity	98%	Storage	Store at 4-8°C
Description	Irosustat, also known as STX64, BN83495 and 667 coumate, is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.