RepSox New
Data Sheet
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| CAS No. | 446859-33-2 | Cat. No. | BCP04103 |
| Name | RepSox | ||
| Synonyms | ALK5 Inhibitor II; E-616452;SJN 2511;E616452;SJN2511;E 616452;SJN-2511; | ||
| SMILES | CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1 | ||
| Chemical Name | |||
| Formula | C17H13N5 | M. Wt | 287.32 |
| Purity | 99% | Storage | Store at 4-8°C |
| Description | RepSox, also known as SJN 2511, E 616452 and ALK5 Inhibitor II, is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. | ||
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