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WIKI4 Chemical Structure

WIKI4

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP15357CAS No. ：838818-26-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 838818-26-1 Cat. No. BCP15357
Name WIKI4
Synonyms WIKI 4; WIKI-4;
SMILES O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O
Chemical Name
Formula C29H23N5O3S M. Wt 521.59
Purity 98% Storage Store at 4-8°C
Description WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. WIKI4 mediates its effects on Wnt/ß-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ß-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors.
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