Cysmethynil
Data Sheet
For research use only. Not for human use.
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| CAS No. | 851636-83-4 | Cat. No. | BCP21581 |
| Name | Cysmethynil | ||
| Synonyms | |||
| SMILES | CCCCCCCCN1C=C(C2=C1C=CC(=C2)C3=CC(=CC=C3)C)CC(=O)N | ||
| Chemical Name | |||
| Formula | C25H32N2O | M. Wt | 376.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt. | ||
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