Cilazapril monohydrate New
Data Sheet
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| CAS No. | 92077-78-6 | Cat. No. | BCP48662 |
| Name | Cilazapril monohydrate | ||
| Synonyms | Ro 31-2848 monohydrate; | ||
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC2CCCN3CCCC(N3C2=O)C(=O)O.O | ||
| Chemical Name | |||
| Formula | C22H33N3O6 | M. Wt | 435.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cilazapril Monohydrate is a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
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