T56-LIMKi
Data Sheet
For research use only. Not for human use.
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| CAS No. | 924473-59-6 | Cat. No. | BCP28984 |
| Name | T56-LIMKi | ||
| Synonyms | T56 LIMKi; T56LIMKi; T5601640; T56-LIM Kinase Inhibitor; | ||
| SMILES | CC1=NOC(=C1)C(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C19H14F3N3O3 | M. Wt | 389.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | T5601640, also known as T56-LIMKi, has high specific inhibitory activity for LIMK2 and shows little or no activity with LIMK1. T5601640 is an inhibitor of LIM kinase 2 (LIMK2) that inhibits LIMK2-mediated cofilin phosphorylation. It reduces the levels of phosphorylated cofilin (p-cofilin) in mouse embryonic fibroblasts (MEF) lacking neurofibromin (Nf1-/-; IC50 = 30 µM), which normally have high levels of p-cofilin. T5601640 (50 µM) decreases actin stress fiber formation, inhibits cell migration, and inhibits colony formation of Nf1-/- MEF cells. It inhibits proliferation of ST88-14, U87, and PANC-1 cells with IC50 values of 18.3, 7.4, and 35.2 µM, respectively, and also decreases p-cofilin levels by 20, 24, and 46%, respectively. Oral gavage administration of T5601640 (60 mg/kg) decreases tumor volume and cofilin phosphorylation in a PANC-1 nude mouse xenograft model. | ||
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