Adavosertib New Hot Discount
Data Sheet
For research use only. Not for human use.
Get Quotation Now
Bulk Inquiry Tel: 0086-13720134139 or orders@biochempartner.com
Real-Time Inquiry ×
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 955365-80-7 | Cat. No. | BCP01928 |
| Name | Adavosertib | ||
| Synonyms | MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775;MK-1775; | ||
| SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O | ||
| Chemical Name | |||
| Formula | C27H32N8O2 | M. Wt | 500.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect. | ||
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.
Recommend Products
More >
Tags:Adavosertib supplier,Adavosertib purchase,Adavosertib manufacturer,Adavosertib distributor,Adavosertib cost,Adavosertib buy,Adavosertib for sale