AGN 196996 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 958295-17-5 | Cat. No. | BCP46996 |
| Name | AGN 196996 | ||
| Synonyms | AGN-196996;AGN196996; | ||
| SMILES | CCOC1=C(C=C(C=C1Br)C(=O)NC2=CC=C(C=C2)C(=O)O)C(=O)C3=CC=C(C=C3)C | ||
| Chemical Name | |||
| Formula | C24H20BrNO5 | M. Wt | 482.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. | ||
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