AP1189 acetate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 959850-74-9 | Cat. No. | BCP46589 |
| Name | AP1189 acetate | ||
| Synonyms | AP 1189 acetate;AP-1189 acetate; | ||
| SMILES | NC(N/N=C/C=C/C1=CC=CN1C2=CC=CC=C2[N+]([O-])=O)=N.CC(O)=O | ||
| Chemical Name | |||
| Formula | C16H18N6O4 | M. Wt | 358.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold. | ||
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