LY2811376 2HCl salt
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1194043-85-0 | Cat. No. | BCP24326 |
| Name | LY2811376 2HCl salt | ||
| Synonyms | LY-2811376 2HCl salt;LY 2811376 2HCl salt; | ||
| SMILES | FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1.[H]Cl.[H]Cl | ||
| Chemical Name | |||
| Formula | C15H16Cl2F2N4S | M. Wt | 393.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY2811376 is a potent and selective BACE1 inhibitor (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin.3 LY2811376 treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage. The β-secretase enzyme, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), cleaves amyloid precursor protein (APP) in the first step in β-amyloid (Aβ) peptide production. Thus, BACE1 is a key target for candidate disease-modifying treatment of Alzheimer's disease. | ||
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