KN62
Data Sheet
For research use only. Not for human use.
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| CAS No. | 127191-97-3 | Cat. No. | BCP02708 |
| Name | KN62 | ||
| Synonyms | KN 62;KN-62; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C38H35N5O6S2 | M. Wt | 721.84 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KN-62 has demonstrated potent and selective inhibition of CaMKII (Ca2+/calmodulin-dependent protein kinase II) (Ki=0.9 μM) which causes cells to arrest in the S phase. In HEK-293 cells expressing III-AC (type III adenylyl cyclase), 10 μM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). | ||
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