EMA401
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1316755-16-4 | Cat. No. | BCP24001 |
| Name | EMA401 | ||
| Synonyms | Olodanrigan; EMA 401 ; EMA-401; | ||
| SMILES | COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5 | ||
| Chemical Name | |||
| Formula | C32H29NO5 | M. Wt | 507.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. target: AT2R In vivo: AngII induces p38, p42/p44 mitogen activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons that is blocked by EMA401. Inhibits capsaicin responses in cultured hDRG neurons. | ||
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