BIBS 39
Data Sheet
For research use only. Not for human use.
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| CAS No. | 133085-33-3 | Cat. No. | BCP17735 |
| Name | BIBS 39 | ||
| Synonyms | BIBS-39;BIBS39; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H34N4O3 | M. Wt | 510.635 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BIBS-39 is a novel, nonpeptide angiotensin II receptor antagonist, showing antihypertensive activity. In contrast to the angiotensin II receptor subtype 1 (AT1) selective drug DuP 753, BIBS-39 also displays affinity for the angiotensin II receptor subtype 2. BIBS 39 displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. BIBS 39 appears to be effective antihypertensives in the model of the renal hypertensive rat. | ||
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