AM2394
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1442684-77-6 | Cat. No. | BCP18588 |
| Name | AM2394 | ||
| Synonyms | AM-2394;AM 2394; | ||
| SMILES | O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CC=C(OCC(C)(O)C)N=C3)C=N1 | ||
| Chemical Name | |||
| Formula | C22H25N5O4 | M. Wt | 423.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. | ||
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