PF-06424439 HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1469284-80-7 | Cat. No. | BCP43813 |
| Name | PF-06424439 HCl | ||
| Synonyms | PF06424439 HCl;PF 06424439 HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H27Cl2N7O | M. Wt | 476.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. | ||
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