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Vimseltinib Chemical Structure

Vimseltinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP44095CAS No. ：1628606-05-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1628606-05-2 Cat. No. BCP44095
Name Vimseltinib
Synonyms DCC-3014; DCC 3014; DCC3014;
SMILES CC1=C(C=CC(=N1)C2=CN=C(N(C2=O)C)NC(C)C)OC3=CC(=NC=C3)C4=CN(N=C4)C
Chemical Name
Formula C23H25N7O2 M. Wt 431.49
Purity 98% Storage Store at 4-8°C
Description Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities. Upon administration, DCC-3014 targets and binds to CSF1R expressed on monocytes, macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory mediators by macrophages and monocytes and reduces inflammation.
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