AZD-2932
Data Sheet
For research use only. Not for human use.
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| CAS No. | 883986-34-3 | Cat. No. | BCP07984 |
| Name | AZD-2932 | ||
| Synonyms | AZD2932;AZD 2932; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H25N5O4 | M. Wt | 447.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | The same C6 in vivo model was used to study tumor growth inhibition (TGI) with AZD2932. Twice daily oral dosing (b.i.d.) 10 h apart resulted in significant TGI of 64% for both 50 and 12.5 mg/kg doses on the day the control animals were terminated (day 22 on the graph). Most importantly, xenografts bearing non-PDGFR expressing tumor cells were also sensitive to AZD2932 treatment: growth of Calu-6 tumor was inhibited by 81% and 72% at 50 and 12.5 mg/kg b.i.d. (p <0.001) and LoVo tumors by 67% at 50 mg/kg b.i.d. (p <0.001). | ||
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