Home   >  
Angiogenesis/Protein Tyrosine Kinase
  • Apoptosis Pathway
  • MAPK Pathway
  >  
Ferroptosis
  • VEGFR
  • FLT3
  • Raf
  >   Donafenib
Donafenib Chemical Structure

Donafenib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP34023CAS No. :1130115-44-4Purity:98%
 Tel: 0086-13026320035   or   orders@biochempartner.com
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • Chemical Properties&Biological Activity
CAS No. 1130115-44-4 Cat. No. BCP34023
Name Donafenib
Synonyms Sorafenib (D3); CM-4307; CM 4307; CM4307;Bay 43-9006 (D3);
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Chemical Name
Formula C21H13D3ClF3N4O3 M. Wt 467.85
Purity 98% Storage Store at 4-8°C
Description Donafenib is an orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival.
  • Quality Control&Technical Support
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.

Recommend Products

More >

Tags:Donafenib supplier,Donafenib purchase,Donafenib manufacturer,Donafenib distributor,Donafenib cost,Donafenib buy,Donafenib for sale

0086-13720134139