LXH254 HCl New
Data Sheet
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| CAS No. | LXH254HCl | Cat. No. | BCP30244 |
| Name | LXH254 HCl | ||
| Synonyms | LXH-254 HCl ;LXH 254 HCl ; LXH254 hydrochloride; LXH-254 hydrochloride; LXH 254 hydrochloride; | ||
| SMILES | O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2.[H]Cl | ||
| Chemical Name | |||
| Formula | C25H26ClF3N4O4 | M. Wt | 538.95 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LXH254 is an orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. | ||
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