Tivozanib hydrochloride hydrate New
Data Sheet
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| CAS No. | 682745-41-1 | Cat. No. | BCP45190 |
| Related Products | 475108-18-0（Tivozanib ） | ||
| Name | Tivozanib hydrochloride hydrate | ||
| Synonyms | Tivozanib HCl H2O; | ||
| SMILES | CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl.O.Cl | ||
| Chemical Name | |||
| Formula | C22H22Cl2N4O6 | M. Wt | 509.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. | ||
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