GNE-140 racemic New
Data Sheet
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| CAS No. | 1809794-70-4 | Cat. No. | BCP37998 |
| Name | GNE-140 racemic | ||
| Synonyms | GNE140 racemic;GNE 140 racemic; | ||
| SMILES | C1COCCN1C2=CC=C(C=C2)C3(CC(=C(C(=O)N3)SC4=CC=CC=C4Cl)O)C5=CSC=C5 | ||
| Chemical Name | |||
| Formula | C25H23ClN2O3S2 | M. Wt | 499.04 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance. | ||
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