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Entecavir hydrate Chemical Structure

Entecavir hydrate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01930CAS No. :209216-23-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 209216-23-9 Cat. No. BCP01930
Name Entecavir hydrate
Synonyms Entecavir monohydrate;
SMILES
Chemical Name
Formula C12H15N5O3.H2O M. Wt 295.29
Purity 98% Storage Store at 4-8°C
Description Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV. Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CL
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