E-Guggulsterone New
Data Sheet
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| CAS No. | 39025-24-6 | Cat. No. | BCP34834 |
| Name | E-Guggulsterone | ||
| Synonyms | Guggulsterone E; | ||
| SMILES | CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C | ||
| Chemical Name | |||
| Formula | C21H28O2 | M. Wt | 312.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. | ||
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