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| CAS No. | 508233-74-7 | Cat. No. | BCP05996 |
| Related Products | 960203-27-4（Vortioxetine hydrobromide） | ||
| Name | Vortioxetine | ||
| Synonyms | Lu AA 21004；LuAA21004； Lu-AA21004； Lu AA21004； AA21004; AA-21004; AA 21004; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H22N2S | M. Wt | 298.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U.S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so-called "serotonin modulator and stimulator." It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM; Norepinephrine transporter (NET) blocker — Ki = 113 nM; 5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%; 5-HT1B receptor partial agonist — Ki = 33 nM; 5-HT1D receptor antagonist — Ki = 54 nM; 5-HT3A receptor antagonist — Ki = 3.7 nM; 5-HT7 receptor antagonist — Ki = 19 nM. | ||
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