8-Hydroxy-2'-deoxyguanosine New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 88847-89-6 | Cat. No. | BCP45539 |
| Name | 8-Hydroxy-2'-deoxyguanosine | ||
| Synonyms | 8-Oxo-2'-deoxyguanosine;8-Hydroxydeoxyguanosine; | ||
| SMILES | C1C(C(OC1N2C3=C(C(=O)NC(=N3)N)NC2=O)CO)O | ||
| Chemical Name | |||
| Formula | C10H13N5O5 | M. Wt | 283.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 8-Hydroxy-2'-deoxyguanosine is a major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dG can potentially mispair with deoxyadenine leading to G-to-T transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (SNPs) in the human genome. The concentration of 8-oxo-dG within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to DNA. | ||
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