Supinoxin New
Data Sheet
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| CAS No. | 888478-45-3 | Cat. No. | BCP44103 |
| Name | Supinoxin | ||
| Synonyms | RX5902; RX5902; RX 5902; | ||
| SMILES | COC1=CC(=CC(=C1)N2CCN(CC2)C(=O)NC3=NC4=C(C=CC(=C4)F)N=C3OC)OC | ||
| Chemical Name | |||
| Formula | C22H24FN5O4 | M. Wt | 441.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Supinoxin, also known as RX-5902, is orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. | ||
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