Uprosertib hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1047635-80-2 | Cat. No. | BCP28203 |
| Name | Uprosertib hydrochloride | ||
| Synonyms | GSK-2141795 hydrochloride;GSK795 hydrochloride;GSK2141795; GSK2141795; GSK 2141795; GSK795; GSK795; GSK 795; | ||
| SMILES | O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)N[C@@H](CC3=CC=C(F)C(F)=C3)CN.Cl | ||
| Chemical Name | |||
| Formula | C18H17Cl3F2N4O2 | M. Wt | 465.71 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Uprosertib hydrochloride is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. | ||
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