WZ4002 New Discount
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| CAS No. | 1213269-23-8 | Cat. No. | BCP02515 |
| Name | WZ4002 | ||
| Synonyms | WZ 4002;WZ-4002; | ||
| SMILES | C=CC(NC1=CC=CC(OC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=C1)=O | ||
| Chemical Name | |||
| Formula | C25H27ClN6O3 | M. Wt | 494.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro. | ||
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