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PF-06459988 Chemical Structure

PF-06459988

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP44108CAS No. ：1428774-45-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1428774-45-1 Cat. No. BCP44108
Name PF-06459988
Synonyms PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988;
SMILES CN1C=C(C=N1)NC2=NC3=C(C(=CN3)Cl)C(=N2)OCC4CN(CC4OC)C(=O)C=C
Chemical Name
Formula C19H22ClN7O3 M. Wt 431.88
Purity 98% Storage Store at 4-8°C
Description PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
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