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Almonertinib Chemical Structure

Almonertinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP38312CAS No. :1899921-05-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1899921-05-1 Cat. No. BCP38312
Related Products 2134096-03-8(Almonertinib hydrochloride) 2134096-06-1(Almonertinib mesylate)
Name Almonertinib
Synonyms HS-10296; HS 10296; HS10296;
SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC
Chemical Name
Formula C30H35N7O2 M. Wt 525.64
Purity 98% Storage Store at 4-8°C
Description Almonertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
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