Entospletinib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09582CAS No. ：1229208-44-9Purity：98%

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Chemical Properties&Biological Activity

CAS No.	1229208-44-9	Cat. No.	BCP09582
Name	Entospletinib
Synonyms	GS-9973; GS 9973;GS9973;
SMILES	C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6
Chemical Name
Formula	C23H21N7O	M. Wt	411.46
Purity	98%	Storage	Store at 4-8°C
Description	Entospletinib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Upon oral administration of entospletinib, this agent may inhibit the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies.

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