Cerdulatinib HCl salt
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1369761-01-2 | Cat. No. | BCP25893 |
| Name | Cerdulatinib HCl salt | ||
| Synonyms | Cerdulatinib HCl；PRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070; Cerdulatinib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H28ClN7O3S | M. Wt | 482 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Â’s within the range of 0.11μM to 0.57μM. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations. | ||
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