YM-244769 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1780390-65-9 | Cat. No. | BCP40417 |
| Related Products | 837424-39-2（YM-244769 2HCl） | ||
| Name | YM-244769 dihydrochloride | ||
| Synonyms | YM-244769 2HCl;YM244769 2HCl;YM 244769 2HCl; | ||
| SMILES | C1=CC(=CC(=C1)N)CNC(=O)C2=CN=C(C=C2)OC3=CC=C(C=C3)OCC4=CC(=CC=C4)F.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H24Cl2FN3O3 | M. Wt | 516.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | YM-244769 dihydrochloride is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3. | ||
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