KHS101 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1784282-12-7 | Cat. No. | BCP30178 |
| Name | KHS101 hydrochloride | ||
| Synonyms | KHS-101 hydrochloride; KHS 101 hydrochloride; KHS-101 HCl; KHS 101 HCl; KHS101 HCl; | ||
| SMILES | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl | ||
| Chemical Name | |||
| Formula | C18H22ClN5S | M. Wt | 375.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KHS101 hydrochloride is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It acts by selectively inducing neuronal differentiation and apoptotic cell death in breast cancer.KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo. | ||
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