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CAS No. | 2309409-79-6 | Cat. No. | BCP49698 |
Name | CMP-5 dihydrochloride | ||
Synonyms | CMP-5 2HCl; | ||
SMILES | CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41.Cl.Cl | ||
Chemical Name | |||
Formula | C21H23Cl2N3 | M. Wt | 388.3 |
Purity | 98% | Storage | Store at 4-8°C |
Description | CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected. |
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