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CAS No. | 327062-46-4 | Cat. No. | BCP33054 |
Name | NS19504 | ||
Synonyms | NS 19504;NS-19504; | ||
SMILES | C1=CC(=CC=C1CC2=CN=C(S2)N)Br | ||
Chemical Name | |||
Formula | C10H9BrN2S | M. Wt | 269.16 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels. |
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