(6R)-FR054 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 35954-65-5 | Cat. No. | BCP43472 |
| Related Products | 10378-06-0（FR054 ） | ||
| Name | (6R)-FR054 | ||
| Synonyms | FR054; FR-054; FR 054;FR054 6R-isomer; | ||
| SMILES | CC1=NC2C(C(C(OC2O1)COC(=O)C)OC(=O)C)OC(=O)C | ||
| Chemical Name | |||
| Formula | C14H19NO8 | M. Wt | 329.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (6R)-FR054 is a less active isomer of FR054.FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. | ||
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