NAE-IN-M22 New
Data Sheet
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| CAS No. | 864420-54-2 | Cat. No. | BCP44660 |
| Name | NAE-IN-M22 | ||
| Synonyms | M22 NEDD8 inhibitor; M22; M-22; M 22; | ||
| SMILES | C1CN(CCC1NCCC2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3 | ||
| Chemical Name | |||
| Formula | C20H24Cl2N2 | M. Wt | 363.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NAE-IN-M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells. Furthermore, it produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in a zebrafish model. M22, a novel NAE inhibitor, represents a promising lead structure for the development of new antitumor agents. | ||
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