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Phlorizin Chemical Structure

Phlorizin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29914CAS No. :60-81-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 60-81-1 Cat. No. BCP29914
Name Phlorizin
Synonyms Phloridzin; phloretin-2'-β-D-glucopyranoside; AI3-19835; NSC 2833; Phloretin 2'-glucoside; Phloretin-2'-O-beta-glucoside; Phlorizoside; Phlorrhizin;
SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O
Chemical Name
Formula C21H24O10 M. Wt 436.41
Purity 98% Storage Store at 4-8°C
Description Phlorizin, also referred to as phloridzin, is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as canagliflozin and dapagliflozin.
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