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Exatecan Chemical Structure

Exatecan

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP30802CAS No. ：171335-80-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 171335-80-1 Cat. No. BCP30802
Name Exatecan
Synonyms DX 8951; DX 8951; DX 8951;
SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O
Chemical Name
Formula C24H22FN3O4 M. Wt 435.45
Purity 98% Storage Store at 4-8°C
Description Exatecan, also known as DX 8951, is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.
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