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Tovinontrine Chemical Structure

Tovinontrine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP44778CAS No. :2062661-53-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2062661-53-2 Cat. No. BCP44778
Name Tovinontrine
Synonyms IMR-687; IMR 687; IMR687;
SMILES CC1CN(CC1C2=CN3C(=CN=C3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
Chemical Name
Formula C21H26N6O2 M. Wt 394.47
Purity 98% Storage Store at 4-8°C
Description Tovinontrine, also known as IMR-687, is a phosphodiesterase 9 (PDE9) inhibitor. IMR-687 increased cGMP and HbF in erythroid K562 and UT-7 cells and increased the percentage of HbF positive erythroid cells generated in vitro using a two-phase liquid culture of CD34+ progenitors from sickle cell blood or bone marrow. Oral daily dosing of IMR-687 in the Townes transgenic mouse SCD model, increased HbF and reduced red blood cell sickling, immune cell activation and microvascular stasis.
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