CFTRinh-172
Data Sheet
For research use only. Not for human use.
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| CAS No. | 307510-92-5 | Cat. No. | BCP15834 |
| Name | CFTRinh-172 | ||
| Synonyms | CFTRinh 172;CFTRinh172; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H10F3NO3S2 | M. Wt | 409.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CFTR(inh)-172 was nontoxic at high concentrations in cell culture and mouse models. At concentrations fully inhibiting CFTR, CFTR(inh)-172 did not prevent elevation of cellular cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(+) channels, or a series of other transporters . Short-circuit current experiments indicated similar CFTR(inh)-172 inhibitory potency (K(i) approximately 0.5 microM) for inhibition of Cl(-) current in wild-type, G551D, and G1349D CFTR; however, K(i) was significantly reduced to 0.2 microM for DeltaF508 CFTR . | ||
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