Crinecerfont hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 321839-75-2 | Cat. No. | BCP43623 |
| Name | Crinecerfont hydrochloride | ||
| Synonyms | SSR 125543 hydrochloride;SSR 125543A; SR125543A; LS-150601; LS150601; LS 150601; | ||
| SMILES | CC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F.Cl | ||
| Chemical Name | |||
| Formula | C27H29Cl2FN2OS | M. Wt | 519.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Crinecerfont is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein. SSR 125543A exhibited antidepressant and anxiolytic properties in the Flinders Sensitive Line rats. | ||
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