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Vandetanib Chemical Structure

Vandetanib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01925CAS No. :443913-73-3Purity:98%
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  • Publications Citing of Biochempartner's Vandetanib
  • Chemical Properties&Biological Activity
CAS No. 443913-73-3 Cat. No. BCP01925
Name Vandetanib
Synonyms Zactima;ZD6474;ZD-6474;ZD 6474;
SMILES
Chemical Name
Formula C22H24BrFN4O2 M. Wt 475.36
Purity 98% Storage Store at 4-8°C
Description Vandetanib also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Vandetanib is not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM, while almost has no activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib inhibits VEGF-, EGF- and bFGF-stimulated HUVEC proliferation with IC50 of 60 nM, 170 nM and 800 nM, with no effect on basal endothelial cell growth. Vandetanib inhibits tumor cell growth with IC50 of 2.7 μM (A549) to 13.5 μM (Calu-6). Vandetanib displays an inhibitory effect on the basal ABCG2-ATPase. Parental and ABCG2-expressing A431 cells showed similar sensitivities toward Vandetanib.
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