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Genz-123346 Chemical Structure

Genz-123346

Data Sheet For research use only. Not for human use.
Cat. No. :BCP11811CAS No. :491833-30-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 491833-30-8 Cat. No. BCP11811
Name Genz-123346
Synonyms Genz123346;Genz 123346;
SMILES
Chemical Name
Formula C24H38N2O4 M. Wt 418.57
Purity 98% Storage Store at 4-8°C
Description Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
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