Tyrosine kinase-IN-1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 705946-27-6 | Cat. No. | BCP30849 |
| Name | Tyrosine kinase-IN-1 | ||
| Synonyms | XL999;XL-999; XL 999; | ||
| SMILES | CCN1CCC(CC1)NC2=CC3=C(C=C2)NC(=O)C3=C(C4=CC(=CC=C4)F)C5=NC=C(N5)C | ||
| Chemical Name | |||
| Formula | C26H28FN5O | M. Wt | 445.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tyrosine kinase-IN-1 is a Spectrum Selective Kinase Inhibitor(TM) (SSKIs), is a potent inhibitor of key RTKs implicated in the development and maintenance of tumor vasculature and in the proliferation of some tumor cells. It inhibits the FGFR, VEGFR and PDGFR RTKs and exhibited excellent activity in target-specific cellular functional assays. In addition, XL999 is a potent inhibitor of FLT3, an important driver of leukemia cell proliferation in some patients with acute myelogenous leukemia (AML). In several preclinical models of human tumors, including breast, lung, colon and prostate cancer, XL999 demonstrated potent inhibition of tumor growth, and also caused regression of large well-established tumors. | ||
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