Camptothecin New
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Publications Citing of Biochempartner's Camptothecin
| CAS No. | 7689-03-4 | Cat. No. | BCP02857 |
| Name | Camptothecin | ||
| Synonyms | Camptothecine (S,+);(S)-(+)-Camptothecin; d-Camptothecin; 20(S)-Camptothecine; (+)-Camptothecin; Camptothecine; CPT; | ||
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O | ||
| Chemical Name | |||
| Formula | C20H16N2O4 | M. Wt | 348.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan. | ||
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