CAL-101 Discount

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02532CAS No. ：870281-82-6Purity：98%

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CAS No.	870281-82-6	Cat. No.	BCP02532
Name	CAL-101
Synonyms	Idelalisib;GS-1101;CAL 101;CAL101; GS1101; GS 1101;
SMILES
Chemical Name
Formula	C22H18FN7O	M. Wt	415.42
Purity	98%	Storage	Store at 4-8°C
Description	CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks Fc?R1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhi